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KMID : 0385219960060010001
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Korean Journal of Gerontology
1996 Volume.6 No. 1 p.1 ~ p.8
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Oxidative stress and antioxidant enzyme activities in Senescence accelerated Mouse
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Park Jong-Wan
Cheong Myong-Hee
Chun Yang-Sook
Park Jong-Kwon
Choi Cheol-Hee
Yoo Ho-Jin
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Abstract
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The Senescence Accelerated Mouse(SAM) is an animal model for aging study which ages earlier than normal mouse. In order to evaluate the roles of oxygen free radicals in aging process, oxidation damage and activities of free radical scavenging enzymes in various organs were compared between senescence-prone (SAM-P) and senescence-resistant (SAM-R) strains of SAM at 10 months of age. SAM-P which looks much older than SAM-R of same age showed higher content of fluorescent age pigment(FAP), particularly in liver and kidney. Conjugated dienes(CD), products of lipid peroxidation were also higher in liver and kidney in SAM-P. These results indicate that SAM-P is more damaged by oxygen free radicals than SAM-R. There were differences in activities of antioxidant enzymes between two substrains. In case of liver mitochondrial superoxide dismutase, SAM-P showed only 60% of SAM-R. Activity of cytosolic glutathione reductase was reduced in kidney, lung and brain of SAM-P. These results suggest that the oxidative stress plays some role in acceleration of aging process in SAM-P.
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KEYWORD
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Senescence Accelerated Mouse, Aging, Oxygen free radical, Antioxidant enzyme
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